The Dr. Hyman Show · 2025-09-24 · 70 min · 12,679 words

Fix Your Brain by Fixing Your Body: Metabolic Psychiatry Explained by Dr. Shebani Sethi

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One in three people have insulin resistance in the United States and that doubles your risk of developing depression even if you have had no psychiatric history. This is this sort of weird moment in psychiatry where I think we're converging these two massive paradigm shifts. One is around psychedelic medicine, metabolic psychiatry. You can't do one without the other.

Dr. Shabani Sethi is the founding director of Stanford's metabolic psychiatry program where she unites nutrition, metabolism, and mental health care. She's rewriting mental health. By fixing the body first, what is metabolic psychiatry? Metabolic psychiatry is thinking about metabolism and mental health.

connection, but it's the study of all of the metabolic dysfunctions, both systemic as well as central. So you can have dysfunction in the brain and you can have dysfunction outside the brain in the body. And those two elements are important in thinking about how that affects psychiatric disease and mental health. The thing that I think people are wondering about is where do I start? Like I'm depressed, I'm anxious, maybe I have bipolar disease, maybe I've got it from schizophrenia.

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