transcript · 2026-08-26 · 12 min · 1,796 words

How your metabolism could alter your mental health

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You're listening to Shortwave. From NPR. In two thousand nine, when Shabani Sethi was in medical school, she met a patient who changed the rest of her career. At the time, Shibani was working at an obesity clinic in North Carolina, and this patient, who wanted to lose weight, was also taking medication for schizophrenia. It's something that she had struggled with for over twenty years and she had tried every

single psychiatric medication. That was available and Ultimately when she underwent a dietary intervention She lost weight and her

Symptoms of schizophrenia improved. Shibani was curious. She looked into the patient's charts, previous medications, and whether there were any recent changes that could explain the patient's schizophrenia symptoms improving. Because I didn't Quite believe that a dietary intervention was the reason. That this change was occurring for her. But as Shibani kept digging through historical medical records, she found hints of this basic idea. A century ago, people understood there was a connection between metabolism, which is how the body turns food into energy.

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