The Dr. Hyman Show · 2026-06-29 · 28 min · 5,831 words

Encore: Why Normal Cholesterol Doesn't Always Mean Low Heart Disease Risk

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Let me ask you this. If cholesterol were truly the main cause of heart disease, then why do half the people who have heart attacks have normal LDL levels? And there was a study of like 136,000 people who had heart attacks went to ER, and 75% had a quote normal LDL level. So that begs the question, then what the hell is going on here? Welcome back to office hours.

Over the summer, we're revisiting a few of the conversations that resonate with most of our audience. And this one was at the very top of the list. When this episode first aired, it sparked a huge response because it challenged something many of us have been told for decades, and that is this. Cholesterol is the primary driver of heart disease. Well, it might not be, and find out why if you listen.

In this conversation, I dive into the latest science around cholesterol and inflammation, around insulin resistance, and something they call APOB, which is super important to know about, and metabolic health. And I ask whether we've been focusing on the wrong markers all along. What's interesting is that since this episode first came out, the conversation around cardiovascular risk has only continued to evolve. And listening back today, many of these insights feel even more relevant than they did the first time. So whether you're hearing about it for the first time or coming back for a second listen,

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