#395 - Brain lipidology: understanding APOE, cholesterol homeostasis, Alzheimer's disease risk, and the effects of lipid-lowering therapies on brain health | Tom Dayspring, M.D.

Hey everyone, welcome to the Drive Podcast. I'm your host, Peter Atia. This podcast, my website, and my weekly newsletter all focus on the goal of translating the science of longevity into something accessible for everyone. Our goal is to provide the best content in health and wellness. And we've established a great team of analysts to make this happen.

It is extremely important to me to provide all of this content without relying on paid ads. To do this, our work is made entirely possible by our members, and in return, we offer exclusive member only content and benefits above and beyond what is available for free. If you want to take your knowledge of this space to the next level, it's our goal to ensure members get back much more than the price of a subscription. If you want to learn more about the benefits of our premium membership, head over to peterateamd.com forward slash subscribe. My guest this week is Dr. Tom Dayspring, who returned to the drive for another deep dive into lipidology, but this time through the lens of the brain. Tom's been a frequent guest on the podcast and has had an extraordinary career. He's an extraordinary teacher, a mentor to me personally, along with many others. And of course a colleague of mine for many years now in the practice. He's one of the most thoughtful lepidologists I know.

with a very remarkable ability to take complex physiology and make it not only clinically relevant but understandable. In this conversation with Tom, we cover the fundamentals of cholesterol transport in the body, mostly just so that those who are coming to this for the first time or, you know, frankly don't remember our earlier discussions on this. have the baseline. But then we really focus on the brain. We talk about why the brain's cholesterol system is almost entirely separate from the peripheral system, that is the rest of the body. We talk about the role of Apo B, which I've talked about a lot, and APO A one, and specifically APOE, as it pertains to cholesterol. So we talk about how the ApoE genotype relates to Alzheimer's disease risk, which is something we referred to a lot, but then the link between Apo E Cholesterol.

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