The Dr. Hyman Show · 2026-06-03 · 54 min · 9,827 words

Antidepressants Explained: Benefits, Risks, and Alternatives for Depression | Dr. James Greenblatt

Listen to the original audio · Transcribed with NVIDIA Parakeet · Timestamps stay in sync with the live audio

Let's talk about antidepressants, what percent are they affected for, who are they affected for, and where are we failing with these medications? For too many years this psychiatric community completely ignored what happens when you stop these medications. I call it withdrawal, they call it discontinuation syndrome, and it was just kind of eye-opening when I had two people stop the same medicine. It was selexa. And one person did it fine.

And the next one had these intractable, you know, brain zaps and suicidal thoughts. And I realized, well, it's not the medicine, it's what's going on in that individual. And once we do the functional testing, we replete the D and the B12 or the amino acids, we can safely withdraw someone from these antidepressants. If you've been listening to this podcast for a while, you've heard me talk about seed before. Now I've reviewed countless of probiotics over the years and seed continues to stand out as the microbiome company really pushing the science forward.

Their DS01 daily symbiotic is the number one digestive health probiotic. It's formulated with 24 clinically studied strains designed to support gut health, healthy regularities, skin health, immune health, and gut barrier integrity, which is important. Now what impressed me most is this level of scientific rigor behind it. In fact, that's what led me to join Seed's clinical board.

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