Infinite Loops · 2026-04-30 · 86 min · 13,858 words

Saloni Dattani - The Hidden Bottleneck Holding Back the Future of Medicine (Ep. 312)

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There are medical breakthroughs in the pipeline right now that work, that won't get to patients for another decade from now. Being able to test whether they work is really important, otherwise we wouldn't know which drugs to prescribe, but it could be done so much more efficiently than it than it is now. Biology and clinical trials are still going to be the bottleneck, even if we have AI to massively speed up like this pattern recognition of trying to find potential drugs. My guest today is Solani Daytoni. We talk about why science journalism so often gets progress wrong, what a magazine is actually for in a substack world, and the hidden bottlenecks in medicine that almost nobody talks about, but that are profoundly important to understand.

Please enjoy my conversation with Solani. Solani, welcome. Thank you. What is going on.

Why is every innovation in healthcare exclusively for the mouse population? That's a great question. It's sort of strange to think about like the fact that we do so much research in animals before we test things out in humans because there's so many differences between us and mice and other um animals. I think part of it is a bit uh of just path dependency.

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