Huberman Lab · 2025-10-30 · 39 min · 7,241 words

Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

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Welcome to Huberman Lab Essentials, where we revisit past episodes for the most potent and actionable science-based tools for mental health, physical health, and performance. I'm Andrew Huberman and I'm a professor of neurobiology and ophthalmology at Stanford School of Medicine. And now my conversation with Dr. David Sinclair. Thanks for being here.

I have a ton of questions for you about aging, longevity, lifespan, actionable protocols to increase how long we live, et cetera. And I just want to start off with a very simple question. What is the difference between longevity, anti-aging, and aging as a disease? Because I associate you with the statement, aging is a disease. Right.

Well, so longevity is the more academic way we describe what we research. Anti-aging It's kind of the same thing, but it's got a bad rap because it's been used by a whole bunch of people that don't know what they're talking about. So I really don't like that term anti-aging. But aging as a disease and longevity are perfectly valid ways to talk about this subject.

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