Huberman Lab · 2025-05-19 · 137 min · 27,716 words

The Science & Art of Comedy & Creativity | Tom Segura

Listen to the original audio · Transcribed with NVIDIA Parakeet · Timestamps stay in sync with the live audio

Welcome to the Huberman Lab Podcast, where we discuss science and science-based tools for everyday life. I'm Andrew Huberman, and I'm a professor of neurobiology and ophthalmology at Stanford School of Medicine. My guest today is Tom Segura. Tom Segura is a renowned comedian, writer, and director. During today's episode, we explore the neuroscience and psychology behind comedy and we explore the creative process more generally.

Tom shares his approach to capturing and developing ideas into narratives that are at once funny and thought-provoking. We discuss the interplay between daily life observations and larger cultural dynamics when developing comedy routines. We spend a fair bit of time discussing the neurobiological basis of humor and what data and brain lesion patients have taught us about why we find certain ideas novel, funny, or exciting. We also talk about how this relates to the activation of reward circuits in the brain and the seemingly automatic way that things are either funny or not funny to people, suggesting that humor is like taste or smell. You really can't negotiate what works for you or what doesn't.

We also discuss emotional contagion and how skilled performers like Tom become masters at reading, shifting, and dancing with the collective energy of crowds, whether in small comedy clubs or large arena shows. So if you're creative or you're curious about human psychology, or if you simply love to laugh, you'll come away from today's episode having learned a ton of useful information about the creative process and human nature. Before we begin, I'd like to emphasize that this podcast is separate from my teaching and research roles at Stanford. It is, however, part of my desire and effort to bring zero cost to consumer information about science and science-related tools to the general public. In keeping with that theme, this episode does include sponsors.

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