Huberman Lab · 2025-07-28 · 147 min · 26,201 words

Male vs. Female Brain Differences & How They Arise From Genes & Hormones | Dr. Nirao Shah

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Welcome to the Huberman Lab Podcast, where we discuss science and science-based tools for everyday life. I'm Andrew Huberman and I'm a professor of neurobiology and ophthalmology at Stanford School of Medicine. My guest today is Dr. Nirao Shah. Dr.

Nirao Shaw is a professor of psychiatry and behavioral sciences and neurobiology at Stanford University School of Medicine. Dr. Shaw is both an MD and a PhD, and his laboratory focuses on understanding the neural and hormonal mechanisms underlying sex differences in the brain. During today's episode, we discuss what is known about male and female differences in brain structure and function, and how those differences arise across development, both in utero and postnatally, that is, during puberty and into adulthood. A lot of our discussion centers around testosterone and estrogen and how both of those hormones play a profound impact on the development of both the male and female brain, but leads to different outcomes in male versus female brains.

We also discussed the neural circuits that control sex behavior and aggressive behavior in both males and females and how those are activated by different hormones. As you all know, There is immense interest and a lot of controversy around sex differences and how that relates to gender. Today's discussion centers around the biology of sex differences in the brain and body, and it will provide a very useful template for everybody in thinking about male versus female differences in behavior, in emotions, and how that intersects with gender and culture. As you'll soon see, Dr.

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