Huberman Lab · 2026-02-23 · 119 min · 19,885 words

Restore Youthfulness & Vitality to the Aging Brain & Body | Dr. Tony Wyss-Coray

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For the first time, we could take an old brain and we could give factors from a young organism and ask, is that going to change the age of the brain? And that's indeed what it did. So we saw that there are stem cells in the brain of these mice, that they got reactivated, there was less inflammation, more activity that we can measure in the brain. And then most importantly, we actually saw that their memory function improved. Welcome to the Huberman Lab Podcast, where we discuss science and science-based tools for everyday life.

I'm Andrew Huberman and I'm a professor of neurobiology and ophthalmology at Stanford School of Medicine. My guest today is Dr. Tony Weiss-Corey. Dr. Tony Weiss-Corey is a professor of neurology at Stanford School of Medicine and an expert in identifying factors that can help prevent and reverse organ degeneration and aging.

Today we discussed the factors that are present in young blood, yes, you heard that right, and the factors that are present in blood after exercise that have been shown to rejuvenate the brain and other tissues in older individuals. Dr. Tony Weiss Corey's lab has discovered several proteins that are present in high amounts when we are young and that circulate in the blood, and that diminish with age, and if these are supplied to the aged body and brain, can reverse key features of aging, including improved cognition, Tissue recovery from stress, damage, and more. We also discuss how aging is nonlinear, it does not progress uniformly across the lifespan.

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