#1040 Luana Colloca: Placebo Effects Through the Lens of Translational Research
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Hello, everybody, welcome to a new episode of the Decenter. I'm your host as always, Ricardo Lopes, and today I'm joined by Dr. Luana Colocca. She is professor in pain and translational symptom science, director of the placebo Beyond Opinion Center, empowered professor and adjunct professor in the Department of Anesthesiology at the University of Maryland, and she is co-editor of placebo effects through the lens of translational research and that's the book we're talking about today so Dr.
Koloka welcome to the show it's a pleasure to have you on thank you so much Ricardo for having me today so uh tell us first before we get into more detail on the topic of placebos particularly for people who might not be familiar with this specific topic what is a placebo exactly Placebo per se are inert substances that were introduced in medicine as comparators with an active drug to validate the efficacy of new drugs. But historically, placebo have been bread pills. saline solution and many other ingredients that were given to patients to please them when no other treatments were available. In fact, some people say that the history of placebo is the history of medicine because 200 years ago and even earlier, 1000 probably, already Hippocrates was mentioning, you know, use of treatment that somehow
were not necessarily linked to an action, but yet were given to help patients to feel better. From that observation that many clinicians were aware of, science started to investigate the mechanisms of placebo effects. Why do we improve symptoms when we believe that a treatment is able to help? And so placebo effects have been studied in the arena of pain, fatigue, anxiety, depression, Parkinson, motor disorders, and so on. And the goal is to try to understand the neurobiology beyond improvement of symptoms related to placebo.
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