Huberman Lab · 2025-09-08 · 165 min · 30,906 words

Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder

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Welcome to the Huberman Lab Podcast, where we discuss science and science-based tools for everyday life. I'm Andrew Huberman and I'm a professor of neurobiology and ophthalmology at Stanford School of Medicine. My guest today is Dr. Michael Snyder. Dr.

Michael Snyder is a professor of genetics at Stanford University School of Medicine. His laboratory focuses on how different people respond differently to different types of food and health interventions. And his overall goal is to figure out how different genes and proteins that different people express impact people's immune system function, reaction to different foods and diets, blood sugar regulation, immune system, and longevity. Today's episode could basically be summarized as, as you suspected, not everybody responds the same way to the same behavioral drug. supplement or other treatment designed to improve health span and lifespan.

For instance, the Snyder Laboratory published a paper earlier this year showing that different people spike insulin in response to different types of carbohydrates. Things like the glycemic index, which we may be familiar with because they are essentially a readout of how much a given food impacts blood sugar. depends on who you are. They identified so-called potato spikers, they literally refer to them as potato spikers in this paper, versus grape spikers, people whose insulin spikes in response to potatoes but not grapes, and vice versa. And while this might seem kind of silly or trivial or micro-slicing, the identification of these different subtypes of people in the general population who respond differently to different types of foods is extremely important because I think most all of us are getting a little bit tired

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