#825: Dr. Dominic D’Agostino — All Things Ketones, How to Protect the Brain and Boost Cognition, Sardine Fasting, Diet Rules, Revisiting Metformin and Melatonin, and More

Hello, boys and girls, ladies and germs. This is Tim Verris. Welcome to another episode where it is yet again my pleasure, after more than a decade, to deconstruct world class performers from all different disciplines to tease out The news you can use, the tactics, and specifics that you can apply to your own life. My guest today is a very popular and repeat. Guest on this show, Dr. Dominic d'Agostino. He is a tenured associate professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida, Morsani College of Medicine, and a visiting senior research scientist at the Institute for Human and Machine Cognition. He's also one hell of an athlete and if you were to ask me to name one person To ask any question related to ketosis

Exogenous ketones, in other words, supplemental ketones, anything at all related to the ketogenic diet, metabolic psychiatry, if I had to choose someone who is a decathlete of the highest order across all of those, it would be Dominic or Dom. He teaches medical neuroscience, physiology, nutrition, and neuropharmacology, and his research focuses on the development and testing of nutritional strategies. We'll talk about that, and metabolic based therapies for neurological disorders. Whether it's depression or chronic inflammation, cancer, and human performance optimization. He has served as a research investigator and crew member on NASA's extreme environment mission operations, and his research has been supported by the Office of Naval Research, the Department of Defense, the National Institutes of Health and Nonprofit Foundations among Others. We get into a lot in this episode. We get very much into the weeds. So I thought I would do something that I rarely do and just share a few of my takeaways. And these are just a small sampling, but I wanted to mention a few things. For instance, I have been taking various types of supplemental ketones, and they come in many different types.

You have ketone salts, sometimes combined with electrolytes, you have ketone esters of different types. They're Are many. different types of supplemental ketones that you can take. A ketone is not a ketone is not a ketone. And I learned, for instance, that if I am consuming something like ketostart, which is a ketone salt that also includes electrolytes, Or if I'm consuming, say, a mono ester or something like that, that I should add MCT oil to the mix, which you can get as an oil, or you can get it powdered. Now, why would you want to do such a thing? Well, straight from Dom, we had a lot of texts before and after this conversation, exogenous BHB. That's Beta hydroxybutrate plus MCT increases BHB higher than either one taken alone. MCT sustains the elevation of BHB salt and esters by slowing.

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